Vardenafil(Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, has been shown to improve erections in up to 80% of men and increase their ability to complete sexual intercourse with ejaculation, according to a presentation at the XVI annual European Association of Urology (EAU) meeting in Geneva, Switzerland. The study was the first large-scale patient trial of vardenafil(Levitra), which is made by Bayer.
“Vardenafil(Levitra) improved erectile function in these men, regardless of their age, cause, or severity of their problem. This improvement occurred even at the lowest dose of 5 mg,” said Dr. Irwin Goldstein, Boston University School of Medicine, a co-author of the study and a member of the international Vardenafil Study Group. “There was another important finding as well,” continued Goldstein. “In the overall study, vardenafil(Levitra) not only helped most men achieve erections, they also were able to sustain their erections and successfully complete intercourse.”
The analyses involved 580 patients, aged 21-70 years, in stable heterosexual relationships, from 39 treatment centers in the United States, Belgium, France, Germany, the Netherlands, Poland, and South Africa. The patients had experienced difficulty with erectile function of organic, psychogenic, or mixed etiology for an average of 2.8 years. They were randomized into 4 groups and received vardenafil(Levitra) in 5 mg, 10 mg, 20 mg doses, or placebo on demand, but not more than once a day.
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read comments (2)The phosphodiesterase type 5 (PDE5) inhibitor vardenafil (Levitra) improves symptoms and digital blood flow, both at room temperature and during a cold-exposure test, in some patients with Raynaud disease, results of a pilot study suggest.
Raynaud disease can be difficult to treat, especially among patients whose disease is secondary to connective tissue diseases, such as systemic sclerosis. In the January 23rd issue of the Archives of Internal Medicine, Dr. Stephan Rosenkranz and colleagues at Universitat zu Koln in Germany suggest that, because PDE5 inhibition is used to treat erectile dysfunction on the basis of its vasodilatory properties, it would be of benefit in patients with Raynaud disease. Read the rest of this entry »
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